Radiation preparation of drug carriers for dexamethasone and tegafur based on poly(n-isopropylacrylamide) hydrogels
Main Article Content
Abstract
Poly(N-isopropylacrylamide) (PNIPAM) based hydrogels with the lower critical solution temperature (LCST) near the human body-temperature have been obtained from 10% solutions of N-isopropylacrylamide (NIPA) and N,N’-dimethyl acrylamide(DMA) mixture of 90:10 and 85:15 (w/w) by radiation copolymerization and crosslinking using a gamma Co-60 source at a dose of 20 kGy. Water swelling behaviour of the resulting hydrogels was much dependent on the initial ratio of NIPA and DMA. The hydrogels of 85:15 NIPA/DMA was chosen for further investigation for the use as drug cariers.Two kinds of drug carriers were prepared by immerging the hydrogels in solutions containing dexamethasone and tegafur. Then the drug incorporation efficiencies and in-vitro release behaviors of the ingredient were analysed. Loading capacities of the hydrogels were about 48.6 and 95.7 mg per g of dried gel for dexamethasone and tegafur, respectively. The results also revealed that the presence of ions in simulated body fluid and solution temperature much affected to the release behaviors of hydrogels for both dexamethasone and tegafur. Release rates of the ingredients were quite fast for both drug models. These drug-loaded hydrogels were biocompatibility without skin irritation suggesting that they may be used as controlled release drug carriers.
Article Details
Keywords
poly (N-isopropylacrylamide), hydrogel, dexamethasone, tegafur, loading capacity, drug release
References
2. Qiu Y, Park K., Environment-sensitive hydrogels for drug delivery. Advanced Drug Delivery Reviews 53: 321-339, 2001.
3. Park K, Park H, Smart hydrogels. In Salamone JC (Ed.): Concise polymeric materials Encyclopedia. CRC Press, Boca Raton, pp. 1476-1478, 1999.
4. Kamath K, Park K., Biodegradable hydrogels in drug delivery. Advanced Drug Delivery Reviews 11: 59-84, 1993.
5. Kishi R, Ichijo H, Hirasa O, Thermo-responsive devices using poly(vinyl methyl ether) hydrogels. Journal of Intelligent Material system structure 4: 533-537, 1993.
6. Hirokawa Y, Tanaka T, Volume phase transition in a nonionic gel. The Journal of Chemical Physics 81: 6379, 1984.
7. Schild HG, Poly(N-isopropylacrylamide): experiment, theory and application. Progress Polymer Science 17: 163-249, 1992.
8. Quynh TM, Lam TD, Dobashi T, Preparation of Thermosensitive Micelles Composed of PLLA-g-P(NIPAM-co-HEMA) Grafted Copolymer for Drug Delivery Systems. The 6th International Workshop on Advanced Materials Science and Nanotechnology (IWAMSN 2012), Halong, 2012.
9. Quynh, TM., Yoneyama, M., Maki, Y., Nagasawa, N., Dobashi, T., Thermosensitive micelles composed of Poly(lactide)-g-Poly(NIPAM-co-HEMA) graft copolymers. Key Engineering Materials 459: 51-56, 2011.
10. Melendez-Ortiz HI, Bucio E, Burillo G., Radiation-grafting of 4-vinylpyridine and N-isopropylacrylamide onto polypropylene to give novel pH and thermo-sensitive films. Radiation Physics and Chemistry 78: 1-7, 2009.
11. Ortega A, Bucio E, Burillo G., Radiation polymerization and crosslinking of (N-isopropylacrylamide) in solution and in bulk. Polymer Bulletin 58: 565-573, 2007.
12. Sang HD, Duong PD, Quynh TM., Radiation polymerization and crosslinking of poly(N-isopropylacrylamide) hydrogels. Vietnam Chemistry Journal 50(5): 597-600, 2012.
13. Pargaonkar N, Lvov YM, LiN, Steenekamp JH, de Villiers MM., Controlled release of dexamethasone from microcapsules produced by polyelectrolyte layer-by-layer nanoassembly. Pharmaceutical Research 22: 826, 2005.
14. Katzung BG. Ed. Chapter 12: Basic and clinical pharmacology. Printice-Hall International, London, 1989
15. Tasdelen B, Kayaman-Apohan N, Guven O, Baysal BM., Preparation of poly(N-isopropylacrylamide/itaconic acid) copolymeric hydrogels and their drug release behaviour. International Journal of Pharmaceutics 278: 343-351, 2004.