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Published: 2019-03-15
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DOI: https://doi.org/10.53747/jnst.v9i1.59
Issue
Vol. 9 No. 1 (2019)
Section
Articles
How to Cite
Tran , M. T., Mai , V. V., Dam, . T. T., Nguyen , Q. A., Le , T. T. H., Pham , M. D., Nguyen , T. A., Nguyen , V. S., Nguyen , T. H., Dang, Q. B., Nguyen , X. V., & Nguyen , T. K. D. (2019). Preparation of ¹⁸F-NaF radiopharmaceuticals using home-made automatic synthesis module at Hanoi Irradiation Center. Nuclear Science and Technology, 9(1), 41-49. https://doi.org/10.53747/jnst.v9i1.59

Preparation of ¹⁸F-NaF radiopharmaceuticals using home-made automatic synthesis module at Hanoi Irradiation Center

Tran Manh Thang1, Mai Van Vinh1, Dam Thi Tam1, Nguyen Quang Anh, Le Thi Thu Hien1, Pham Minh Duc1, Nguyen Tuan Anh, Nguyen Van Sy1, Nguyen Thanh Hung1, Dang Quang Bao1, Nguyen Xuan Vinh1, Nguyen Thi Kim Dung2
1 Hanoi Irradiation Center. Km12, Road 32, Minh Khai, Tu Liem North, Hanoi, Vietnam
2 Nuclear Medicine Department, 108 Military Central Hospital. No. 1, Tran Hung Dao, Hai Ba Trung, Hanoi, Vietmam

Main Article Content

Abstract

The aim of this study is to prepare 18F-NaF radiopharmaceutical using a home-made
automatic synthesis module consisting of hardware and software which was made by a researcherteam of Hanoi Irradiation Center, HIC, Hanoi, Vietnam. Fluorine-18 isotopes produced in cyclotron KOTRON13 were transferred to the module and radioactive cation impurities were first removed by cation exchange on a carboxymethyl cation exchange (CM) cartridge, and then 18F- ion were trapped by a quaternary methyl ammonium anion exchange (QMA) cartridge. Finally, 18F- was eluated from the cartridge by isotonic saline water (NaCl 0,9% in water) in the form of 18F-NaF. Time of the preparation process was about 13 minutes. Radiochemical yield of the preparation was as high as 95.5%, in average. The qualities of the product were satisfied the criteria of the United States
Pharmacopoeia (USP38). PET/CT bone scaner (skeletal scintigraphy) pre-clinical tests using of the 18 F-NaF product showed good quality of imaging for the entire skeletal and distribution of the 18F-NaF in the kidney and the bladder agreed with it’s natural distribution.

Article Details

Keywords

Sodium [F-18]-fluoride radiopharmaceutical, KOTRON13 cyclotron, Synthesis module, bone scan

References

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