Article Sidebar

PDF
Published: 2019-03-15
Abstract Views: 157
Views PDF: 64
DOI: https://doi.org/10.53747/jnst.v9i1.59
Issue
Vol. 9 No. 1 (2019)
Section
Articles
How to Cite
Tran , M. T., Mai , V. V., Dam, . T. T., Nguyen , Q. A., Le , T. T. H., Pham , M. D., Nguyen , T. A., Nguyen , V. S., Nguyen , T. H., Dang, Q. B., Nguyen , X. V., & Nguyen , T. K. D. (2019). Preparation of ¹⁸F-NaF radiopharmaceuticals using home-made automatic synthesis module at Hanoi Irradiation Center. Nuclear Science and Technology, 9(1), 41-49. https://doi.org/10.53747/jnst.v9i1.59

Preparation of ¹⁸F-NaF radiopharmaceuticals using home-made automatic synthesis module at Hanoi Irradiation Center

Tran Manh Thang1, Mai Van Vinh1, Dam Thi Tam1, Nguyen Quang Anh, Le Thi Thu Hien1, Pham Minh Duc1, Nguyen Tuan Anh, Nguyen Van Sy1, Nguyen Thanh Hung1, Dang Quang Bao1, Nguyen Xuan Vinh1, Nguyen Thi Kim Dung2
1 Hanoi Irradiation Center. Km12, Road 32, Minh Khai, Tu Liem North, Hanoi, Vietnam
2 Nuclear Medicine Department, 108 Military Central Hospital. No. 1, Tran Hung Dao, Hai Ba Trung, Hanoi, Vietmam

Main Article Content

Abstract

The aim of this study is to prepare 18F-NaF radiopharmaceutical using a home-made
automatic synthesis module consisting of hardware and software which was made by a researcherteam of Hanoi Irradiation Center, HIC, Hanoi, Vietnam. Fluorine-18 isotopes produced in cyclotron KOTRON13 were transferred to the module and radioactive cation impurities were first removed by cation exchange on a carboxymethyl cation exchange (CM) cartridge, and then 18F- ion were trapped by a quaternary methyl ammonium anion exchange (QMA) cartridge. Finally, 18F- was eluated from the cartridge by isotonic saline water (NaCl 0,9% in water) in the form of 18F-NaF. Time of the preparation process was about 13 minutes. Radiochemical yield of the preparation was as high as 95.5%, in average. The qualities of the product were satisfied the criteria of the United States
Pharmacopoeia (USP38). PET/CT bone scaner (skeletal scintigraphy) pre-clinical tests using of the 18 F-NaF product showed good quality of imaging for the entire skeletal and distribution of the 18F-NaF in the kidney and the bladder agreed with it’s natural distribution.

Article Details

Keywords

Sodium [F-18]-fluoride radiopharmaceutical, KOTRON13 cyclotron, Synthesis module, bone scan

References

[1]. Natalia M. Leonardi, Guillermo A. Casale, Jorge Nicolini, Patricia D. Zubata, and Marıa J. Salgueiro. Validation of a paper chromatographic methodology as an alternative for determination of the radiochemical purity of Na18F, Nucl. Med. Technol., 40: 271-274, 2012.
[2]. Yuan H., Merrill J. R., Parrott M. and Anzellotti A. [18F]NaF Manufacture via the ABT BG75 system. Imaging and Biodistribution studies.” University of North Carolina at Chapel Hill, NC27599, School of Medicine, pp.1-6.
[3]. Mark S. Jacobson, Raymond A. Steichen, and Patrick J. Peller. PET radiochemistry and radiopharmacy", Springer-Verlag Berlin Heidelberg, 703: 19-30, 2012.
[4]. Rajeev Kumar, Rajendra G. Sonkawade, Madhavi Tripathi, Punit Sharma, Priyanka Gupta, Praveen Kumar, Anil K. Pandey, Chandrasekhar Bal, Nishikant Avinash Damle, and Gurupad Bandopadhayaya. Production of the PET bone agent 18F-fluoride ion, simultaneously with 18F-FDG by single run of the medical cyclotron with minimal radiation exposure - A novel technique, Hell J. Nucl. Med., 17: 106-110, 2014.
[5]. Brian G. Hockley and Peterj H. Scott. An automated method for preparation of [18F] sodium fluoride for injection, USP to address the technetium-99m isotope shortage. Appl. Radiat. Isot., 68: 117-119, 2010.
[6]. Jae Yong Choi, Ji Woong Lee, Kyo Chul Lee, Kyeong Min Kim, Young beom Seo, Jung Young Kim, Young Hoon Ryu. Time and cost effective production of sodium [18F]fluoride using a dedicated automation module with disposable cassettes for GMP environment. J. Radioanal. Nucl. Chem., 309: 938-987, 2016.
[7]. Frederick D. Grant, Frederic H. Fahey, Alan B. Packard, Royal T. Davis, Abass Alavi, and S. Ted Treves. Skeletal PET with 18F-Fluoride: Applying new technology to an old tracer. The J. of Nucl. Med., 49(1): 68-78, 2008.
[8]. Nuclear and Radiation Studies Board Division on Earth and Life Studies. Opportunities and approaches for supplying molybdenum-99 and associated medical isotopes to Global Markets. In Proc of a Sym. Washington, DC. The National Academies Press. Chapter 3: Current molybdenum-99 supply, pp. 13-17, 2018.
[9]. Modular-Lab PharmTracer, Cassette-based routine production of 18F tracers, Eckert & Ziegler, https://radiopharma.com/wp-content/uploads/2018/01/7131-0077.pdf (7131-0077/Rev.04/05. 2019). Accessed on 19 November 2019.
[10]. Bernard Lambert, Jean-Jacques Cavelier, Guillaume Gauron, Christophe Sauvage, Cécile Kech, Tim Neal, M. Kiselev,David Caron, Anat Shirvan, Ilan Ziv. Routine automated production of 18F-labelled radiopharmaceuticals on IBA Synthera® Multi-Purpose Platform. Presented at the 13th WTTC 2010 in RISOE/Denmark., Abstract No.016, 2010.
[11]. CharlotteCollet, Muhammad Otabashi, Fabrice Giacomelli ,Nicolas Veran, Gilles Karcher, Yves Chapleur, Sandrine Lamandé-Langle. Fully automated production of sodium [18F]fluoride on All In One and mini All In One synthesizers. Appl. Radiat.and Isot., 102: 87-92, 2015.
[12]. The United States Phamacopeial Convention, “Sodium FluorideF-18 Injection”, USP38, pp. 3546-3547, 2015.