Simulation of absorbed doses distribution in a polyethylene phantom for BNCT application at the Dalat research reactor

Pham Dang Quyet1, Pham Ngoc Son2, Nguyen Nhi Dien2, Nguyen An Son1, Trinh Thi Tu Anh1, Cao Dong Vu2
1 The University of Dalat, 01 Phu Dong Thien Vuong Street, Dalat, Lamdong
2 Nuclear Research Institute, 01 Nguyen Tu Luc Street, Dalat, Lamdong

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Abstract

In this paper, the distribution of absorbed dose components in a polyethylene phantom for BNCT application at Dalat Nuclear Research Reactor (DNRR) were calculated using the MCNP5 code. The configuration of horizontal neutron channel No.2 of the DNRR, which contains a cylindrical collimator with neutron filters of 20-cm Si and 3-cm Bi, was simulated. The results show that the gamma dose along the central axis of the phantom has the maximum value of 1.82×10-6 Gy at the 0.5-cm depth, and reduces to 9.05×10-7 Gy at the 3-cm depth. The main contribution to gamma dose is due to the interaction of thermal neutron with hydrogen in the phantom via the 1H(n,γ)2H reaction, and its value is much smaller than thermal neutron dose. The total absorbed dose along the central axis of the phantom has the maximum value of 7.87×10-5 Gy at the 0.5-cm depth, and decreases rapidly to 1.52×10-5 Gy at the 3-cm position, and mainly depends on the boron and thermal neutron doses caused by the 10B(n, α)7Li and 14N(n, p)14C reactions, respectively.

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References

[1]. Barth R. F., Soloway A. H. and Fairchild R. G., “Boron Neutron Capture Therapy of Cancer”, Cancer Research, 50, pp. 1061-1070, 1990.
[2]. Barth R. F., Vicente M. G. H., Harling O. K. et al., “Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer”, Radiation Oncology, 7, pp. 146, 2012.
[3]. Matsumoto T., “Design of neutron beams for boron neutron capture therapy for Triga reactor”, Journal of Nuclear Science and Technology, 33 (2), pp.171-178, 1996.
[4]. Barth R. F., Coderre J. A., Vicente M. G. H. and Blue T. E., Boron Neutron Capture Therapy, Current Status and Future Prospects, pp. 431-459, 2005.
[5]. Myong-Seop K., Byung-Chul L., Sung-Yul H. et al., “Development and characteristics of the HANARO neutron irradiation facility for applications in the boron neutron capture therapy field”, Phys. Med. Biol., 52, pp. 2553- 2566, 2007.
[6]. Brockman J., Nigg D. W., Hawthorne M. F. and McKibben C., “Spectral performance of a composite single-crystal filtered thermal neutron beam for BNCT research at the University of Missouri”, Applied Radiation and Isotopes, 67, pp. 223-225, 2009.
[7]. Nigg D. W. and Eng D., “Methods for radiation dose distribution analysis and treatment planning in boron neutron capture therapy”, Int. J. Radiat. Oncol. Biol. Phys., 28(5), pp. 1121-1134, 1994.
[8]. Kasesaz Y., Bavarnegin E., Golshanian M. et al., “BNCT project at Tehran Research Reactor: current and prospective plans”, Progress in Nuclear Energy, 91, pp. 107, 2016.
[9]. Monshizadeh M., Kasesaz Y., Khalafi H. and Hamidi S., “MCNP design of thermal and epithermal neutron beam for BNCT at the Isfahan MNSR”, Progress in Nuclear Energy, 83, pp. 427-432, 2015.
[10]. Allen B. J, Moore D. E. and Harrington B. V., Progress in neutron capture therapy for cancer, New York, 1992.
[11]. Yamamoto T., Matsumura A., Yamamoto K., Kumada H., Shibata Y. and Nose T., “Inphantom two-dimensional thermal neutron distribution for intraoperative boron neutron capture therapy of brain tumours”, Phys. Med. Biol. 47, pp. 2387–2396, 2002.
[12]. Solleh M. R. M., Mohamed A. A., Tajuddin A.A., Rabir M. H., Zin M. R. M., Yazid H., Azman A., Yoshiaki K. and Hiraga F., Neutron and gamma measurement with water phantom for boron neutron capture therapy (BNCT) reactor Triga Puspati, 2014.
[13]. Bavarnegin E., Sadremomtaz A., Khalafi H. and Kasesaz Y., “Measurement of in-phantom neutron flux and gamma dose in Tehran research reactor boron neutron capture therapy beam line”, J. Canc. Res. Therapy, 12(2), 2016.
[14]. Pham Dang Quyet, Pham Ngoc Son, Nguyen Nhi Dien, Trinh Thi Tu Anh and Cao Dong Vu, “Simulation design of thermal neutron collimators for neutron capture studies at the Dalat Research Reactor”, Asian Journal of Scientific Research, 13(3), pp. 214-218, 2020.
[15]. Nguyen Nhi Dien et al., Utilisation of the Dalat Research Reactor after its core conversion, Joint IGORR 2014/ IAEA Technical Meeting, 17–21 November, Bariloche, Argentina, 2014.
[16]. Pham Ngoc Son, Vuong Huu Tan, Nguyen Nhi Dien, Nguyen Xuan Hai, Tran Tuan Anh, Ho Huu Thang and Cao Dong Vu, “Development of thermal filtered neutron beam based on the radial channel No. 2 of Dalat research reactor”, The Annual Report for 2010, Science and Technics Publishing House, pp. 21-27, 2010.
[17]. Nakagawa Y., Pooh K., Kobayashi T. et al., “Clinical review of the Japanese experience with boron neutron capture therapy and a proposed strategy using epithermal neutron beams”, J. Neuro-Oncol., 62, pp. 87-99, 2003.
[18]. Masouli S. F., “Simulation of the BNCT of brain tumors using MCNP code: beam designing and dose”, Iran J. Med. Phys., 9 (3), 2012.